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Our group studies bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells that will autonomously divide. Our primary interest lies in mobile division, chromatin construction, and spatial Manage.
Again in 1991, Sumio Iijima of the NEC Company had documented the synthesis of carbon nanotubes. Band construction calculations advised that these nanotubes could exhibit metallic band conduction. This might be a major edge in excess of the conducting polymers we had explored, which have been, the truth is, disordered semiconductors giving simply variable-assortment hopping conductivity.
2007, to start with authentic-time detection of strand exchange in homologous recombination by RecA; discovery of the lower persistence length of finishes of microtubules; and settled the mechanism of biosensing with carbon nanotubes
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The coiled-coil on the human Rad50 DNA restore protein incorporates distinct segments of elevated adaptability
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Just lately his investigation has focused on researching cell division with bacteria on chip, when his supreme interest is during the route of realizing artificial cells.
Atomic drive microscopy shows that vaccinia topoisomerase IB generates filaments on DNA within a cooperative vogue
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But carbon nanotubes have remained a exploration matter of significant curiosity to several. Certainly, the outlook on utilizing carbon nanotubes to build sensible devices, in areas which include radio-frequency electronics, electronic electronics and flexible electronics, remains bright.
‘The concept You can find such a matter as a starting, a giant bang, is now a fascinating signpost to ceesdekker think about that there was a creator. But a lot more generally, and on The premise of pure rationality, I also get there in a Christian interpretation of truth. An atheistic worldview is often a naturalistic worldview: essentially, you will find only atoms and organic forces that we could measure.
‘That concerns the synthetic mobile, as A part of the Dutch BaSyC initiative. Craig Venter seemed top-down in Individuals times and identified about five hundred genes that happen to be minimally needed for the performing cell. We want to glance base-up: how do we transfer from the couple of molecules to a whole Organic system?
2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-range conformational alterations in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in the nanopore
‘I am driven by question and inquiries. On a fabric amount I obtain answers in physics, but I encounter my deepest joy with God. That faith also drives my science And the way I take care of persons.